2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-106646
    CQP-201403 81855-35-8 98%
    CQP-201403 is a dopamine receptor agonist. CQP-201403 can be used for the research of neurological disease.
    CQP-201403
  • HY-106652
    SUN-N8075 dimethanesulfonate 224450-56-0 98%
    SUN-N8075 dimethanesulfonate is a radical scavenger with antioxidant and neuroprotective effect. SUN-N8075 dimethanesulfonate can inhibit apoptosis and ROS production. SUN-N8075 dimethanesulfonate can protect against 6-OHDA (HY-B1081)-induced cell death. SUN-N8075 dimethanesulfonate can be used for the research of neurological disease, such as Parkinson's disease.
    SUN-N8075 dimethanesulfonate
  • HY-106659
    SCH 900978 873947-10-5 98%
    SCH 900978 (NK-1 Antagonist 1) is an antagonist of NK-1 receptor, used in the research of NK-1 related diseases and conditions such as cough, overactive bladder, alcohol dependency and depression.
    SCH 900978
  • HY-106660
    BP 897 hydrochloride 314776-92-6 99.84%
    BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM).
    BP 897 hydrochloride
  • HY-106661
    GLY-230 320777-05-7 98%
    GLY-230 is an orally active compound. GLY-230 can inhibit nonenzymatic glycation and reduce glycated albumin. GLY-230 can reduce brain Aβ42 levels. GLY-230 can be used for the researches of metabolic and neurological disease, such as diabetic renal dysfunction.
    GLY-230
  • HY-106670
    Dulozafone 75616-02-3 98%
    Dulozafone (F1933) shows anticonvulsant activity and can be used for epilepsy research.
    Dulozafone
  • HY-106716
    SR 41378 93181-85-2 98%
    SR 41378 is an orally active aminopyrazine derivative. SR 41378 has anticonvulsant, antianxiety and hypnotic activities.
    SR 41378
  • HY-106732
    AT-076 1657028-64-2 98%
    AT-076 is an opioid pan antagonist at nociception, kappa, mu, and delta opioid receptors, with Ki values of 1.75 nM (NOP), 1.67 nM (MOP), 1.14 nM (KOP) and 19.6 nM (DOP), respectively.
    AT-076
  • HY-106736
    Etilefrine pivalate hydrochloride 42145-91-5 98%
    Etilefrine pivalate hydrochloride is an orally active compound and can be used for study of migraine headaches.
    Etilefrine pivalate hydrochloride
  • HY-106740
    CI-933 91829-95-7 98%
    CI-933 is a nootropic. CI-933 can be used for the research of neurological disease.
    CI-933
  • HY-106741
    Bazinaprine 94011-82-2 98%
    Bazinaprine (SR 95191), a derivative of Minaprine (HY-B0884), is an orally active inhibitor of type A monoamine oxidase (MAO). Bazinaprine can be used for research of depression.
    Bazinaprine
  • HY-106748
    Nictiazem 95058-70-1 98%
    Nictiazem is a 1,5-benzothiazepine derivative. Nictiazem exhibits antidepressant activity and can be used in the research of neurological diseases such as depression.
    Nictiazem
  • HY-106749
    E-0747 99599-78-7 98%
    E-0747 is an antiarrhythmic drug that inhibits arrhythmias by inhibiting Na[+] channels in cardiomyocytes.
    E-0747
  • HY-106752
    CI-936 98383-40-5 98%
    CI-936 (MRS-3310) is an orally active A2 agonist with 25 nM affinity. CI-936 produces potent and selective effects in preclinical tests predictive of antipsychotic efficacy. CI-936 inhibits exploratory activity in mice.
    CI-936
  • HY-106756
    Spiradoline 87151-85-7 98%
    Spiradoline (U-62066), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a Ki of 8.6 nM in guinea pig. The Ki values of Spiradoline for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier.
    Spiradoline
  • HY-106780
    Ecabapide 104775-36-2 98%
    Ecabapide (DQ 2511) is an orally active gastroprokinetic agent. Ecabapide can ameliorate gastric emptying of stroke-prone spontaneously hypertensive rat model. Ecabapide can be studied in research on autonomic nervous system disorder.
    Ecabapide
  • HY-106781
    OPC-4392 111073-34-8 98%
    OPC-4392 is a orally active presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. OPC 4392 reverses the Reserpine (HY-N0480)-induced dopamine accumulation, inhibits Apomorphine (HY-12723)-induced stereotypic and climbing behaviors in mouse models. OPC-4392 can be used as antipsychotic agent.
    OPC-4392
  • HY-10679A
    PF-03049423 402955-58-2 98%
    PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke.
    PF-03049423
  • HY-106820
    BRL 34778 86580-77-0 98%
    BRL 34778 is a potent, selective and orally active dopamine D2 receptor antagonist with a Ki of 2.14 nM. BRL 34778 exhibits antipsychotic activity with low activity for extrapyramidal effects and sedation. BRL 34778 can be used for the research of neurological disease, such as schizophrenia.
    BRL 34778
  • HY-106821
    Cebaracetam 113957-09-8 98%
    Cebaracetam (ZY 15119) is a neuroprotective agent. Cebaracetam can improve cognitive impairment and can be used for the research of neurological disease.
    Cebaracetam
Cat. No. Product Name / Synonyms Application Reactivity